SR-FACT microscopy reveals the landscape of the cellular organelle interactome
(PHYSorg.com Physics)

The emergence of superresolution (SR) fluorescence microscopy has rejuvenated the search for new cellular sub-structures and dynamic intermediates. However, limited by the broad emission spectrum of fluorophores and excessive phototoxicity, SR fluorescence microscopy can only be used to highlight a handful of biomolecules simultaneously and is incapable of providing a holistic map of the cellular environment and landscape.