Chlorthalidone vs. Hydrochlorothiazide to Treat Hypertension
(WorldNews Health)

Study Questions: Is hydrochlorothiazide (HCTZ) as effective and safe compared to chlorthalidone as a first-line therapy for hypertension? Methods: Data from the LEGEND (Large-Scale Evidence Generation and Evaluation in a Network of Databases) observational comparative cohort study were used for the present analysis. Outpatient and inpatient care episodes of first-time users of antihypertensive monotherapy in the United States based on two administrative claims databases and one collection of electronic health records were analyzed. The exposures of interest were use of chlorthalidone and HCTZ. The primary outcomes were acute myocardial...