Restoring protein homeostasis improves memory deficits in Down syndrome model
(PHYSorg.com Medicine & Health)

Down syndrome is the most common genetic cause of intellectual disability, and currently there is no effective treatment. Memory deficits are a hallmark of this condition and a study published today in the journal Science reports that the defects in a conserved stress pathway dubbed the `integrated stress response,` or ISR, could explain the cognitive deficits in a mouse model of Down syndrome.