Sex Differences and Myocardial Fibrosis in Aortic Stenosis
(World News Science)

Study Questions: In calcific aortic stenosis (AS), myocardial fibrosis has been associated with increased morbidity and mortality. This study examined two surrogate markers of myocardial fibrosis derived from cardiac magnetic resonance (CMR) imaging: late gadolinium enhancement (LGE), a marker of replacement myocardial fibrosis, and extracellular volume (ECV) fraction, a marker of diffuse reactive myocardial fibrosis. What are the determinants of LGE and ECV - in particular, sex - in patients with mild to severe AS? Methods: This was a cross-sectional analysis of 249 patients from two prospective...