CRISPR screen reveals new targets in more than half of all squamous cell carcinomas
(PHYSorg.com Medicine & Health)

A little p63 goes a long way in embryonic development-and flaws in p63 can result in birth defects like cleft palette, fused fingers or even missing limbs. But once this early work is done, p63 goes silent, sitting quietly in the genome from that point forward. Unless it is accidentally reactivated. When p63 comes back to life within the adult genome, the result can be cancer. More than half of all squamous cell carcinomas, often found in the skin, lung, breast, and head/neck, involve excess p63 activity.