US hospitals testing experimental therapies to prevent two common bacterial infections
(PHYSorg.com Medicine & Health)

The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, is supporting U.S. clinical sites participating in two ongoing international Phase 2 clinical trials evaluating investigational antibody-based therapies aimed at preventing potentially antibiotic-resistant infections. By aligning the NIAID Antibacterial Resistance Leadership Group (ARLG) with a large international consortium leading the effort, the U.S. investigators hope to enroll 30 adult patients from 15 intensive care units in the trials. NIAID is supporting the domestic sites with a grant to Duke University, Durham, North Carolina, which is part of the ARLG-a clinical research consortium working to reduce the impact of antimicrobial resistance. The larger international trials are supported by MedImmune, the global biologics research and development arm of AstraZeneca, based in Gaithersburg, Maryland, and the Brussels-based Innovative Medicines Initiative Joint Undertaking and the Combatting Antimicrobial Resistance in Europe (COMBACTE) consortium.