Hit-to-lead studies on a novel series of small molecule inhibitors of DHODH
(PHYSorg.com Chemistry)

The enzyme dihydroorotate dehydrogenase (DHODH), an essential component for the de novo pyrimidine ribonucleotide biosynthesis, has reemerged in the last few years as a target for the development of small molecules with anticancer and antiviral activity.