CRISPR base editors can induce wide-ranging off-target RNA edits
(PHYSorg.com Biology)

A Massachusetts General Hospital (MGH) research team reports that several of the recently developed CRISPR base editors, which create targeted changes in a single DNA base, can induce widespread off-target effects in RNA, extending beyond the targeted DNA. Their report receiving advance online publication in Nature also describes engineering variant base editors that significantly reduced the incidence of RNA edits while also increasing the precision of on-target DNA editing.