Urocortin 3 gene therapy increases systolic and diastolic function in heart failure
(PHYSorg.com Medicine & Health)

Mice with heart failure that were treated with AAV8-based gene therapy to deliver the protein urocortin 3 (UCn3) had increased blood levels of UCn3 over a 5-week period and improved heart function. The mice received a single injection of AAV8.UCn3 after cryoinjury to induce left ventricular heart failure and showed significant improvements in both systolic and diastolic heart function, as re-ported in an article published in Human Gene Therapy.