Synthetic receptors can rewire cell functions and minimize side-effects
(PHYSorg.com Chemistry)

One of the challenges of modern pharmacology is specificity. Despite therapeutic effects, drugs can often have side effects. The biological basis for this has to do with the proteins and receptors that the drug targets and binds to. Many target receptors are connected to more than one biochemical pathway or more commonly, the drug is not specific enough to exclusively bind one particular receptor.