Active delivery of Cas9-sgRNA complex in the cell by using ultrasound-propelled nanomotors
(PHYSorg.com Nanotechnology)

In cancer research, the `Cas-9-sgRNA` complex is an effective genomic editing tool, but its delivery across the cell membrane to the target (tumor) genome has not yet been satisfactorily solved. American and Danish scientists have now developed an active nanomotor for the efficient transport, delivery, and release of this gene scissoring system. As detailed in their paper in the journal Angewandte Chemie, their nanovehicle is propelled towards its target by ultrasound.