PUMA pathway is a weak link in breast cancer metastasis
(PHYSorg.com Medicine & Health)

Substantial advancements have improved the success of chemotherapy, radiation, and surgical treatments for primary breast cancers. However, breast cancer that has spread, or metastasized, to other parts of the body remains a challenge to cure. It is difficult to predict whether a tumor will recur and metastasize, and uncertainty can lead to inadequate or overaggressive treatment.